RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE A INVOLUÇÃO UTERINA RETARDADA EM VACAS -/- Emanuel Isaque Cordeiro da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim [email protected] ou [email protected] WhatsApp: (82)98143-8399 -/- 2. INVOLUÇÃO UTERINA RETARDADA -/- A involução uterina retardada é uma desordem reprodutiva parcialmente ocasionada por problemas nutricionais. Terminados os mecanismos do parto, os órgãos genitais da fêmea sofrerá alterações em seu tamanho, peso e forma, eles reduzem de tamanho até sua normalização, esse processo é conhecido como involução uterina (...) (LANDAETA-HERNÁNDEZ, et al. 2004); a sua duração pode variar entre quatro a oito semanas, embora idealmente deva ser atingida aos 30 dias, é mais rápida em vacas de primeiro parto, bem como em vacas que amamentam os seus bezerros e pode ser retardada em vacas que tiveram problemas nutricionais (mal alimentadas ou até desnutridas), partos gêmeos, distorcias e retenção placentária. A recuperação do útero pós-parto ou involução uterina depende de contrações miometriais, eliminação da possível infecção bacteriana e regeneração do endométrio. A regeneração como tal, é denominada involução microscópica e usualmente segue à involução macroscópica ou de redução de peso e tamanho. Esta última pode levar entre 2 a 4 semanas e a primeira, entre 4 a 6 semanas (FRAZER, 2005; GORDON, 1996). A eliminação dos loquios e a redução do tamanho uterino são causadas por contrações miometriais, devidas inicialmente à presença de estrogênio durante o parto e posteriormente à secreção sustentada de prostaglandinas após o parto, as quais aumentam o tônus uterino e assim promovem a involução. Quando, de forma anormal, o período de involução se prolonga além dos mecanismos fisiológicos normais, define-se a situação como retardo na involução uterina com riscos potenciais de redução da eficiência reprodutiva, pela maior probabilidade de desenvolvimento de metrite, alteração da ciclicidade pós-parto e posteriores falhas na implantação por falhas na recuperação endometrial. 2.1 Relação energia e proteína O excesso de energia antes do parto pode levar ao retardo na involução uterina por que, a acumulação em excesso de reservas, se faz na forma de tecido adiposo, o qual ao ser mobilizado, durante o periparto, em resposta à busca pelo animal de fontes de energia para a depleção do glicogênio hepático e para a redução do consumo de matéria seca, deve ativar mecanismos gliconeogênicos (ZUÑIGA, 2006). Entre os substratos para a gliconeogênese incluem-se, em primeiro lugar, o tecido adiposo. Um rápido sinal endócrino para sua mobilização provém do cortisol (em excesso durante o parto), mas na presença de grande quantidade de tecido adiposo se apresentará dois efeitos imediatos; o primeiro uma cetose aguda e o segundo a infiltração da gordura do fígado, também chamado fígado graxo. Estas duas situações alteram a homeostase, em especial do tecido uterino (que sob pouca oferta de glicose, já que a mesma está sendo utilizada por outros tecidos que na compartimentalização enérgica prevalecem sobre o tecido reprodutivo), não é abundante, assim, o miométrio não deve ter energia para manter a contractilidade induzida pelas prostaglandinas. Adicionalmente as prostaglandinas são estruturalmente um ácido graxo insaturado composto por 20 átomos de carbono (ácido araquidônico) que necessita da enzima ciclo-oxigenase que dá origem à síntese de compostos intermediários instáveis chamados endoperóxidos cíclicos (PGG e PGH) (BARRERA, 2003), indispensáveis para a formação da prostaglandina e que não podem ser sintetizados por estar alterado o mecanismo lipogênico. Da mesma forma, o fator contrário em relação ao balanço energético preparado, isto é, em casos de deficiência de energia no preparo, leva a involução uterina retarda mediante um mecanismo que finalmente se assemelha ao apresentado em excesso de energia, mas através de um processo fisiológico em alguns pontos diferentes. Dependendo da gravidade do déficit energético, o catabolismo tecidular pode atingir magnitudes exageradas e, se a ele se somam os excessos de amônio formado pelo déficit de energia a nível ruminal, é provável que fenômenos fisiológicos se convertam em patológicos. A rápida perda de condição corporal, afeta o desempenho reprodutivo devido aos efeitos da excessiva taxa de mobilização dos tecidos sobre a saúde do útero e sua motilidade, já que não se encontrará possibilidade de síntese de prostaglandinas por déficit nos precursores lípidos e tampouco haverá glicose disponível como combustível energético, além disso, o atraso na involução uterina está intimamente relacionada com o balanço energético negativo (BEN) e os seus efeitos na concentração de metabolitos que influenciam o balanço hormonal, em especial sobre os estrógenos. Igualmente, no início da lactação o balanço energético negativo é o resultado de uma alta relação entre a hormona do crescimento e a insulina no sangue, que promove a mobilização de ácidos graxos de cadeia longa do tecido adiposo (ZUÑIGA, 2006). O BEN provoca alterações nas concentrações de metabolitos e hormonas como a glicose, a insulina, a hormona do crescimento (GH) (GALVIS, et al. 2003) e o fator insulínico de crescimento tipo 1 (IGF-1)que estão envolvidos no metabolismo energético intermediário e informam do estado nutricional do hipotálamo afetando a secreção de GnRH atrasando, dessa maneira, o tempo de involução uterina. Ações bloqueadoras mediadas por opioides endógenos que freiam a liberação de FSH e dela derivada, ocorre uma menor síntese de estrogênios que ativam receptores específicos no endométrio e não promovem contractilidade endometrial. Para suprir as necessidades das fêmeas quanto a proteínas e energias, os farelos de milho, soja, arroz, algodão, girassol, amendoim, etc., suprem muito bem as quantidades necessárias. Para tanto, faz-se necessário o cálculo correto das quantidades a serem disponibilizadas na ração, bem como ao cálculo da quantidade fornecida no cocho para o animal, uma vez que a ingestão superior de determinados elementos como o molibdênio, a exemplo, podem causar diversos transtornos para além dos reprodutivos. As forrageiras podem suprir as fontes de energia e proteínas das fêmeas, como as leguminosas por exemplo, em especial a leucena, que serve como alternativa alimentar para a alimentação dos animais, porém mesmo com o fornecimento à vontade das forrageiras como os capins, é necessária uma complementação e a ração concentrada é o melhor remédio para tal. 2.2 Minerais Sabe-se que as deficiências de alguns minerais, incluindo o cálcio, fósforo, cobalto, cobre, iodo, manganês e selênio e os excessos de molibdênio afetam diretamente o sistema reprodutivo (MONCADA, 2001). Suas deficiências correm paralelas com alterações do eixo hipotálamo-hipófise-ovário. Sendo o cálcio um elemento indispensável na contractilidade do útero, seu déficit na dieta poderia ser responsável por uma involução uterina inadequada (RÚGELES, 2001). O cobalto é necessário no rúmen para a formação da vitamina B12. Quando ocorre uma deficiência de cobalto observa-se, primeiro, uma diminuição no consumo de alimentos e, com isso, uma baixa síntese de glicose, um consumo anormal de minerais (pica ou depravação do gosto) e uma queda na produção. Como consequência, pode-se afetar indiretamente, tanto a quantidade de nutrientes consumidos como seu aproveitamento refletindo-se finalmente sobre a fertilidade em forma negativa (DEHNING, 1988). As exigências nutricionais de cobalto em bovinos de corte ou leite, são escassas a nível de pesquisas, porém pode-se obter através da ingestão de matéria seca (MS) sobre um coeficiente fixo que é 0,1, esse número é o pico do fornecimento de cobalto, uma vez ultrapassado a quantidade de 0,1 mg/kg os animais serão acometidos por altos índices de toxidade, por isso o criador deve estar atento ao fornecimento desse microelemento aos animais. Porém, segundo estudos, o intervalo sugerido em quantidades desse elemento é de 0,07 e 0,11 mg/kg. Alguns cereais podem disponibilizar o cobalto em concentrações ideais, porém é melhor a prevenção, sendo assim, a deficiência de cobalto pode ser prevenida ou tratada mediante a adição de sais de cobalto às misturas minerais ingredientes da ração fornecida aos animais, ou pode-se optar pela injeção da vitamina B12 diretamente no animal. Da mesma forma que a deficiência de cálcio e fósforo, na deficiência de cobre, é observado um aumento da involução uterina retardada, calores silenciosos e ciclos estrais irregulares, uma vez que as funções deste mineral estão associadas às enzimas relacionadas com o citocromo C oxidase, transporte de albumina e ceruloplasmina, esta última de vital importância como principal oxidadora de ferro e ativadora nos processos de regulação dos mecanismos antioxidantes a nível celular. Não deve-se esquecer a estreita relação entre cobre e molibdênio. Excessos de molibdênio inibem a absorção de cobre. Em animais criados à pasto, deve-se estar atento a áreas onde as concentrações de molibdênio são mais presentes, se houver grande quantidade desse elemento nas forrageiras que o animal consumir, a melhor maneira de suplementação do cobre nesses animais é a injeção periódica de compostos a base de cobre, que evitarão a complexação do trato gastrointestinal. Os bovinos requerem 8,0 mg/kg (4 – 10 mg/kg) de cobre na dieta para corte e de 10,0 mg/kg (9 – 11 mg/kg) na dieta para bovinos leiteiros. Além da opção de ração que contenha esses níveis de cobre, o criador pode optar pelas forragens, que possuem quantidades variadas de cobre dependendo da disponibilidade do mesmo no solo, e que as leguminosas apresentam os melhores valores para que os animais possam consumir as quantidades essenciais para que não haja nem cobre demais nem cobre de menos no organismo, e que evite-se, com isso a involução uterina ou quaisquer outra doença reprodutiva ou não. A deficiência de iodo induzida pelo consumo de forragens com níveis inferiores a 2 mg/kg de Matéria Seca (MS) ou baixa suplementação mineral, induz a retenção de membranas fetais e involuções uterinas retardadas. A tiroxina (T4) e a triiodotironina (T3) estimulam a produção de ATP mitocondrial, o que, por sua vez, estimula a captação celular de oxigênio e aumenta o metabolismo energético. Em casos de deficiência de iodo, as tiroxinas não poderão ser sintetizadas (RÚGELES, 2001). -/- REFERÊNCIAS BIBLIOGRÁFICAS BARRERA, R. Las prostaglandinas: Estrategia Farmacológica. Portal Veterinária. Disponível em:-. Acesso em: março de 2020. BERCHIELLI, Telma Teresinha; PIRES, Alexandre Vaz; OLIVEIRA, SG de. Nutrição de ruminantes. Jaboticabal: funep, 2006. BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. DA SILVA, Emanuel Isaque Cordeiro. Reprodução Animal: Fisiologia do Parto e da Lactação Animal. Disponível em:-. Acesso em: Março de 2020. DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. GALVIS GÓEZ, Rubén Darío; CORREA CARDONA, Héctor J. Interacciones entre el metabolismo y la reproducción en la vaca lechera: es la actividad gluconeogénica el eslabón perdido?. Rev. Col. Cienc. Pec. Vol. 15:Pág.1-15. 2002. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. LANDAETA-HERNÁNDEZ, A. J. et al. Effect of biostimulation on uterine involution, early ovarian activity and first postpartum estrous cycle in beef cows. Theriogenology, v. 61, n. 7-8, p. 1521-1532, 2004. MONCADA, A. H. Implicaciones metabólicas en el aborto bovino. Seminario de Nutrición, Reproducción y Clínica de Bovinos. Universidad de Antioquia, Medellin. 2001. MORAES, S. da S. Principais deficiências minerais em bovinos de corte. Campo Grande, MS: Embrapa Gado de Corte, 2001., 2001. RÚGELES, Clara. Interrelaciones entre nutrición y fertilidad en bovinos. Revista MVZ Córdoba, p. 24-30, 2001. ZUÑIGA, F. D. Prevención de desordenes metabólicos en la etapa pre y pos parto en bovinos de leche. Engormix. Disponível em:-. Acesso em: março de 2020. (shrink)

Las personas somos absolutamente diferentes de las cosas, no cabe ninguna duda al respecto. No obstante, sí debemos diferenciar nítidamente entre los individuos y el concepto de “persona”. Así pues, la persona posee un “horizonte interior”, absolutamente novedoso y que le caracteriza como ser en aproximación a la Verdad y a la Libertad, las cuales no sólo son específicas del propio humano, sino que le son necesarias en cuanto remedios contra la desolación y la tiranía. Asimismo, una sociedad puede ser (...) tiránica en varios sentidos, pero Manuel Mindán sostiene que, para que no lo sea, el individuo entendido como “persona” debe primar siempre sobre el grupo gregario y cerrado. (shrink)

Aquí se presenta un avance de la investigación acerca de la filosofíaandina prehispánica que parte de la organización de los fragmentos,textos o relatos hallados en los documentos de extirpación deidolatrías, de las crónicas de los españoles, de los informes de lacasta sacerdotal del virreinato, registrados durante la colonizaciónespañola del Perú. En éste, en lo fundamental, se presenta laargumentación sobre la teoría del pensamiento y los problemasfundamentales de la filosofía. Se trata del contenido monumentaldel pensamiento filosófico andino prehispánico perdido entre laabundancia (...) de argumentos y comunicaciones de carácter religioso,mágico y mítico dominante. Con esto esperamos demostrar que síexistió filosofía en el mundo andino prehispánico según un esquemaacorde a la matriz planteada por la filosofía occidental griega. (shrink)

En esta investigación se demuestra que no existe oposición antagónica entre la filosofía andina prehispánica y el desarrollo de la filosofía en general, ni con la filosofía occidental griega en particular, salvo en las formas de su temática especial o la profundización del problema filosófico concreto, por cuanto en ningún caso es contraria a la ley del desarrollo filosófico en general, y de ella debemos entender que los nombres, los términos o los vocablos con que designan los conceptos siendo distintos (...) tienen el mismo contenido y sigue igual lógica de desarrollo. Por ejemplo, “Pacha” resulta una formulación más cercana al concepto científico de espacio/tiempo, por cuanto adelanta la imposibilidad de separar el espacio y el tiempo de los objetos o fenómenos de la realidad objetiva, logrado no como un descubrimiento científico sino como una necesidad de formular el pensamiento acerca de dicho fenómeno, tan semejante a la ciencia moderna. O Cay y Camac, los conceptos de “materia” y de “realidad ideal”, perdidos u ocultos en los textos prehispánicos, son categorías que resuelven los problemas fundamentales de la filosofía, como acerca de “¿Cuál es el “verdadero ser”?”, o acerca de la relación ser y pensar. De igual modo consideramos que el idealismo andino prehispánico no difiere antagónicamente del idealismo griego clásico, contrariamente es posible discutir en el mismo nivel con Platón o con cualquier idealista de la filosofía clásica griega. (shrink)

The idea that citizens have a right to receive information that is relevant for their suitable exercise of political rights and liberties is well established in democratic societies. However, this right has never been systematically analyzed, thus remaining a blurry concept. This article tackles this conceptual gap by conceptualizing citizens’ right to information. After reviewing previous approaches to this idea, I locate citizens’ right to information on the map of communication rights, and put forward a systematic framework for both justifying (...) and analyzing it. This framework focuses on this right’s grounds, its function, its holders, its content, and its correlative duties. Although the conceptualization offered here will be incomplete, it will be enough to distinguish the general concept of citizens’ right to information from both its specific conceptions and from the other two best-known rights of the public: freedom of information and the public’s right to know. (shrink)

Aunque el populismo es uno de los conceptos políticos más empleados en nuestra época, suele decirse que también es uno de los más escasamente comprendidos (Taggart 2002, 62), y hay incluso quien cree que está rodeado de un “completo caos conceptual” (Müller 2016, 11). También hay quien ha intentado clasificar diferentes aproximaciones al populismo (véase especialmente Taggart 2000, 10-22; también Panizza 2005, 2-3; Rovira Kaltwasser 2012, 186-96; Weyland 2017, 51-55). Sin embargo, lo cierto es que el principal consenso académico sobre (...) el populismo es, precisamente, que no hay ningún gran consenso sobre lo que pueda ser el populismo. Por eso hay quien dice que el populismo es un ejemplo paradigmático de lo que Gallie (1955) denominó “conceptos esencialmente controvertidos” (Weyland 2001; Mudde y Rovira Kaltwasser 2013; 2017). -/- Semejantes dificultades para acordar una definición permiten explicar por qué prácticamente cualquier texto académico sobre el populismo empieza advirtiendo que en este debate hay que andar con pies de plomo. Así las cosas, esta entrada no aspira a ofrecer ninguna definición concluyente del populismo (para intentos de ese tipo, véase Mansbridge y Macedo 2019 o Urbinati 2019b). Cada sección tiene una aspiración más modesta. La primera identifica algunas dificultades que complican la comprensión y definición del populismo. La segunda sección presenta dos rasgos en los que, a pesar de las discrepancias, la mayoría de las definiciones del populismo coinciden. La tercera ofrece una reconstrucción sintética de la teoría populista desarrollada por Laclau y Mouffe –dos de los teóricos más influyentes tanto política como académicamente. (shrink)

Recent epistemology has witnessed a substantial opposition between two competing approaches to capturing the notion of non-accidentality in the analysis of knowledge: the explanationist and the modalist. According to the latest advocates of the former, S knows that p if and only if S believes that p because p is true. According to champions of the latter, S knows that p if and only if S's belief that p is true in a relevant set of possible worlds. Because Bogardus and (...) Perrin's explanationism promises to deliver a plausible analysis of knowledge without any need for modal notions, it is an elegant proposal with prima facie appeal. However, such version of explanationism ultimately does not live up to its promises: in this paper, I raise some objections to their explanationist analysis of knowledge while showing that modalism is in much better shape than they think. In particular, I argue that their explanationist condition generates the wrong results in Gettier cases and fake-barn cases. I also offer and defend a novel version of modalism: I introduce a refined safety condition which is shown to successfully handle the same Gettier cases that beset Bogardus and Perrin's version of explanationism. The paper concludes with a reassessment of the explanationist's initial ambition to provide an analysis of knowledge without modal notions. The upshot will be that even if the prospects for such analysis remain dim, our money should be on the modalist, not the explanationist. (shrink)

Recent experimental epistemology has devoted increasing attention to folk attributions of epistemic justification. Empirical studies have tested whether lay people ascribe epistemic justification in specific lottery-style vignettes (Friedman and Turri 2014, Turri and Friedman 2015, Ebert et al. 2018) and also to more ordinary beliefs (Nolte et al. 2021). In this paper, I highlight three crucial but hitherto uncritically accepted assumptions of these studies, and I argue that they are untenable. Central to my criticism is the observation that epistemic justification (...) is a philosophical term of art mostly foreign to lay people: as such, it is not suitable for direct empirical testing without being previously introduced. This point reveals a folk conceptual gap between the subject matter of these experimental studies and the conceptual repertoire we can reasonably expect lay people to possess. I elaborate on this worry, and I end on a cautiously optimistic note: after suggesting better strategies to survey folk attributions of epistemic justification, I conclude that the challenge raised by the folk conceptual gap remains difficult but can in principle be addressed. (shrink)

This article explores how readers recognize their personal identities represented through data visualizations. The recognition is investigated starting from three definitions captured by the philosopher Paul Ricoeur: the identification with the visualization, the recognition of someone in the visualization, and the mutual recognition that happens between readers. Whereas these notions were initially applied to study the role of the book reader, two further concepts complete the shift to data visualization: the digital identity stays for the present-day passport of human actions (...) and the promise is the intimate reflection that projects readers towards their own future. This article reflects on the delicate meaning of digital identity and the way of representing it according to this structure: From Personal Identity to Media is a historical introduction to self-recognition, Data Visualization for Representing Identities moves the focus to visual representation, and The Course of Recognition breaks the self-recognition in through the five concepts above just before the Conclusion. (shrink)

My essay aims to demonstrate that Neoliberalism exercises its art of government on forms of life turning their potentiality into adaptability. According with one of most influential reference thinker of Neoliberalism, Friedrich von Hayek, the spontaneous order of the market requests the constant adaptation of individuals to circumstances of which no one can be aware and can master. However, such adaptability – that could come from a certain negative philosophical anthropology – is the reverse side of the same potentiality theorized (...) by authors of Italian Thought like Agamben, Esposito and exponents of Post-Operaism. The paper aims to focus the condition for which such conversion of potentiality into adaptability is prevented. (shrink)

The Ethical Dimension of Science According to Mariano Artigas: Many authors have written, from different approaches, about the relationships between ethics and science. In this work, we analyze how Mariano Artigas did it. He gives great importance to ethics, which he considers a philosophical presupposition of scientific activity. A detailed analysis of his work allows to understand to what extent ethics is important for science. Specifically, we consider the relationships of ethics with humans and with science; the interweaving and the (...) distinction between both of them; the importance of ethics as a hermeneutical key in Popper; and the emergence of ethics before, during, and after scientific activity. (shrink)

In this paper, I develop and motivate a novel formulation of the safety condition in terms of etiological proper function. After testing this condition against the most pressing objections to safety-theoretic accounts of knowledge in the literature, my conclusion will be the following: once safety is suitably understood in terms of etiological proper function, it stands a better chance as the right anti-Gettier condition on knowledge.

In a recent publication Tom Douglas and Katrien Devolder have proposed a new account of genetic parenthood, building on the work of Heidi Mertes. Douglas and Devolder’s account aims to solve, among other things, the question of who are the genetic parents of an individual created through somatic cell nuclear transfer (i.e. cloning): (a) the nuclear DNA provider or (b) the progenitors of the nuclear DNA provider. Such a question cannot be answered by simply appealing to the folk account of (...) genetic parenthood, according to which the genetic parents of an individual are those individuals who produced the egg and sperm, respectively, which fused to create the embryo. It cannot be so as in cloning there is no fertilization as such. In this article I critically examine Douglas and Devolder’s new account of genetic parenthood and demonstrate that it is vulnerable to counterexamples that exploit the lack of a condition specifying that genetic parents should cause a child’s coming into existence. (shrink)

This book introduces readers to the topic of explanation. The insights of Plato, Aristotle, J.S. Mill and Carl Hempel are examined, and are used to argue against the view that explanation is merely a problem for the philosophy of science. Having established its importance for understanding knowledge in general, the book concludes with a bold and original explanation of explanation.

Karl Christian Friedrich Krause and Georg Wilhelm Friedrich Hegel are two representatives of German Idealism, both of whom developed impressing category systems. At the core of both systems is the question of the relation of the Absolute to its determinations and the determinations of finite beings. Both idealists try to deduce their respective category systems from the immediacy of the Absolute. Both use combinatorial methods to get from known to new categories or constellations in the system, which then unfold in (...) the world. Krause is thereby considered the eponym of so-called panentheism, the doctrine that “Everything is in God.” Hegel is also often referred to as a panentheist. Through a comparison of the two systems of categories, in this essay the thesis will be advocated that Hegel was in no sense a panentheist. Krause is and remains the gold standard of panentheism. (shrink)

The scope of public reason determines which political decisions should be taken according to its standards. In this paper, I defend a broad-scope view of public reason, according to which every single political decision should be justified by public reasons. In the first part, I argue that, despite the unclarity of Rawls’ position, it is compatible with the wide-scope view. In the three following parts, I refute the main arguments in favour of the narrow-scope view of public reason. Finally, I (...) offer an argument for the wide-scope view and conclude that it is preferable from the point of view of political liberalism. (shrink)

Roger Penrose is known for his proposals, in collaboration with Stuart Hameroff, for quantum action in the brain. These proposals, which are still recent, have a prior, less known basis, which will be studied in the following work. First, the paper situates the framework from which a mathematical physicist like Penrose proposes to speak about consciousness. Then it shows how he understands the possible relationships between computation and consciousness and what criticism from other authors he endorses, to conclude by explaining (...) how he understands this relationship between consciousness and computation. Then, it focuses on the concept of non-locality so essential to his understanding of consciousness. With some examples, such as impossible objects or aperiodic tiling, the study addresses the concept of non-locality as Penrose understands it, and then shows how far he intends to arrive with that concept of non-locality. At all times the approach will be more philosophical than physical. (shrink)

If reduction of the social to the physical fail, what options remain for understanding their relationship? Two such options are supervenience and constructivism. Both are vitiated by a similar fault. So the choices are limited: reduction after all, or emergence.

La investigación de la filosofía andina prehispánica, como historia de la filosofía, tiene el propósito descubrir los conceptos de la filosofía en un proceso histórico semejante al de la ciencia presocrática y el idealismo clásico griego, nada distinto de ellas. Esta describe la evolución de las ideas del hombre andino prehispánico, los conceptos que elaboró, manejo y uso en su pensamiento. El concepto de filosofía que asume deviene de Nietzsche, en cuanto pensamiento que se desarrolla con conceptos; la filosofía como (...) el juego de los conceptos, contestando a la pregunta que Engels, planteaba acerca de la relación entre el pensar y el ser, donde nacen los conceptos elementales de la filosofía; ella también sirve para explicar la relación de nuestros pensamientos con el mundo q.ue nos rodea, de si nuestro pensamiento es capaz de conocer el mundo real, de si con nuestras ideas podemos formarnos una imagen refleja exacta del mundo. Es decir, nuestra investigación responde en qué medida el pensamiento andino prehispánico, como indica Hegel, es la teoría del conocimiento de su tiempo, como un pensamiento que se ocupa de sí mismo porque es el objeto de estudio, como pensamiento que “se piensa a sí mismo” respecto sus diferentes determinaciones. (shrink)

A discussion of three central ideas in action theory; trying to act, doing or acting, one's action causing further consequences.

Some Comments on de Melo-Martin and Harris.

In this paper I argue that some human reproductive genome editing interventions can be therapeutic in nature, and thus that it is false that all such interventions just create healthy individuals. I do this by showing that the conditions established by a therapy definition are met by certain reproductive genome editing interventions. I then defend this position against two objections: (a) reproductive genome editing interventions do not attain one of the two conditions for something to be a therapy, and (b) (...) some reproductive genome editing interventions are therapeutic but in a nonstandard way. In the Conclusion I call for a more nuanced discussion of the nature of reproductive genome editing interventions. (shrink)

This paper argues that Spinoza held substances other than God to be inconceivable. It uses this claim to develop a novel response to the Problem of Other Substances, the problem of explaining why some of Spinoza’s proofs for God’s existence cannot be used to prove the existence of a non-divine substance instead.

Recent breakthroughs in stem cell differentiation and reprogramming suggest that functional human gametes could soon be created in vitro. While the ethical debate on the uses of in vitro generated gametes (IVG) was originally constrained by the fact that they could be derived only from embryonic stem cell lines, the advent of somatic cell reprogramming, with the possibility to easily derive human induced pluripotent stem cells from any individual, affords now a major leap in the feasibility of IVG derivation and (...) in the scope of their potential applications. In this paper we develop an ethical framework, rooted in recent scientific evidence, to support a robust experimental pipeline that could enable the first-in-human use of IVG. We then apply this framework to the following objectives: (1) a clarification of the genetic parenting options afforded by IVG, along with their ethical underpinnings; (2) a defence of the use of IVG to remedy infertility, broadening their scope to same-sex couples; (3) an assessment of the most far-reaching implications of IVG for multiplex parenting. These include, first, the liberation of parenting roles from the constraints of biological generations in vivo, allowing multiple individuals to engage in genetic parenting together, thus blurring the distinction between biological and social generations. Second, we discuss the conflation of IVG with sequencing technology and its implications for the possibility that prospective parents may choose among a hitherto unprecedented number of potential children. In view of these perspectives, we argue that, contrary to the exhausted paradigm according to which society lags behind science, IVG may represent instead a salient and most visible instance where biotechnological ingenuity could be used in pursuit of social experimentation. (shrink)

In virtue of what are later and an earlier group members of one and the numerically same tradition? Gallie was one of the few philosophers to have engaged with issues surrounding this question. My article is not a faithful exegesis of Gallie but develops a terminology in which to discuss issues surrounding the numerical identity of a tradition over time, based on some of his insights.

This article develops a diagnostic lens to make sense of the still baffling development of a ‘humanitarian marketplace’. Ambivalently hybrid initiatives such as volunteer tourism, corporate social responsibility or even fair trade do not strictly obey a distributive logic of market exchange, social reciprocity or philanthropic giving. They engender a type of ‘economy’ that must be apprehended in its own terms. The article argues that the large-scale collaborative effects of such a dispersed market can be theorized without resorting to the (...) classical biopolitical move of simplified agency/holistic reification. The argument proceeds counterintuitively, by appropriating the notion of symbiosis as redefined by contemporary biology, contending through historical contextualization and conceptual work that nature itself offers the best example to grasp spontaneous collaboration among unrelated human beings as a non-automatically balanced and intrinsically political affair that calls for critical management through an ex post facto interventionist policy of selective cultivation. (shrink)

The article argues that the famous debate on natural and positive law between Lon Fuller and HLA Hart rests on a dispute about whether or not that something is a law provides on its own a prima facie reason for doing something.

Organiza los relatos, fragmentos y testimonios de la filosofía andinda prehispánica, las mismas que se encuentran en las fuentes documentales registrados durante la colonia, a modo de historia de la filosofía, acompañado de la crítica correspondiente.

John Searle sets out five statements, the relation of each to its successor being one of entailment.

News about the first baby born after a mitochondrial replacement technique (MRT; specifically maternal spindle transfer) broke on September 27, 2016 and, in a matter of hours, went global. Of special interest was the fact that the mitochondrial replacement procedure happened in Mexico. One of the scientists behind this world first was quoted as having said that he and his team went to Mexico to carry out the procedure because, in Mexico, there are no rules. In this paper, we explore (...) Mexico's rule of law in relation to mitochondrial replacement techniques and show that, in fact, certain instances of MRTs are prohibited at the federal level and others are prohibited at the state level. According to our interpretation of the law, the scientists behind this first successful MRT procedure broke federal regulations regarding assisted fertilization research. (shrink)

In this article I try to shed some light on the complex relation between democracy, political knowledge, and disinformation. To do so, I first define three related concepts which, once clarified, could facilitate our understanding of the problems digital democracies face. First, drawing from the general notion of competence, I define civic competence. Then, drawing from the general notion of knowledge, I define political knowledge. Finally, and drawing from the general notion of information, I define democratically relevant information. After clarifying (...) these concepts, I will present three epistemic positions, to which I will refer to as knowledge, ignorance, and mistake. These three epistemic positions will be further connected with informative phenomena such as disinformation, fake news, and misinformation. (shrink)

Is the thought that having a reason for action can also be the cause of the action for which it is the reason coherent? This is an attempt to say exactly what is involved in such a thought, with special reference to the case of con-reasons, reasons that count against the action the agent eventually choses.

In the first wave of the COVID-19 pandemic, healthcare workers in some countries were forced to make distressing triaging decisions about which individual patients should receive potentially life-saving treatment. Much of the ethical discussion prompted by the pandemic has concerned which moral principles should ground our response to these individual triage questions. In this paper we aim to broaden the scope of this discussion by considering the ethics of broader structural allocation decisions raised by the COVID-19 pandemic. More specifically, we (...) consider how nations ought to distribute a scarce life-saving resource across healthcare regions in a public health emergency, particularly in view of regional differences in projected need and existing capacity. We call this the regional triage question. Using the case study of ventilators in the COVID-19 pandemic, we show how the moral frameworks that we might adopt in response to individual triage decisions do not translate straightforwardly to this regional-level triage question. Having outlined what we take to be a plausible egalitarian approach to the regional triage question, we go on to propose a novel way of operationalising the ‘save the most lives’ principle in this context. We claim that the latter principle ought to take some precedence in the regional triage question, but also note important limitations to the extent of the influence that it should have in regional allocation decisions. (shrink)

What might it mean to say that there is such a thing as a hermeneutic circle in the social sciences? A consideration of some remarks by Charles Taylor and others and an interpretive reconstruction, and assessment, of the idea of such a circle.

What constitutes numerically one and the same tradition diachronically, at different times? This question is the focus of often violent dispute in societies. Is it capable of a rational resolution? Many accounts attempt that resolution with a diagnosis of ambiguity of the disputed concept-Islam, Marxism, or democracy for example. The diagnosis offered is in terms of vagueness, namely the vague criteria for sameness or similarity of central beliefs and practices.

Metaphysically speaking, just what is trying? There appear to be two options: to place it on the side of the mind or on the side of the world. Volitionists, who think that to try is to engage in a mental act, perhaps identical to willing and perhaps not, take the mind-side option. The second, or world-side option identifies trying to do something with one of the more basic actions by which one tries to do that thing. The trying is then (...) said to be identical with the physical action. -/- After carefully stating the second, world-side view, I produce two arguments against it. The first relies on the fact that if a=b and b=c, then a=c, sometimes put colloquially as: if something is identical to two things, then the two things must be identical to one another. In the case of trying, one might try to do something by performing a plurality of simultaneous actions, a sure sign that the relation between the trying and the plurality of actions by which one tries must be some relation other than identity. -/- The second argument discusses two cases, recorded in William James’ The Principles of Psychology, of a patient who tries but who performs no action whatever. This is sometimes called ‘naked trying’. A recent attempt at denying that there can be such cases of naked trying is examined and dismissed. (shrink)

It has been commonplace to equate Foucault’s 1979 series of lectures at the Collège de France with the claim that for neoliberalism, unlike for classical liberalism, the market needs to be artificially constructed. The article expands this claim to its full expression, taking it beyond what otherwise would be a simple divulgation of a basic neoliberal tenet. It zeroes in on Foucault’s own insight: that neoliberal constructivism is not directed at the market as such, but, in principle, at society, arguing (...) that the value of this insight goes beyond the critique of a neoliberal present. The neoliberal rationale rather helps him to reveal a unique historical architecture, a latent approach to the social dissimilar to the one that has long predominated in the human sciences. The inversion of homo œconomicus in neoliberal theory amounted to the unearthing of a ‘social subject of interest’ within civil society. Such a subject, barely recognized by neoliberals who simply instrumentalize it for the sake of the market, demonstrates that the social is not necessarily the natural product of ethical subjects; that society may also need to be constructed. (shrink)

Argument that Marx has a realist ontology and a correspondence theory of truth. His views are compared to both Hegel's and Kant's. This interpretation departs from more Hegelian, 'idealist' interpretations that often rely on misunderstanding some of the work of the early Marx. There is also a discussion and partial defence of Lenin's Materialism and Empirio-Criticism.

A comparison of disjunctive theories of action and perception. The development of a theory of action that warrants the name, a disjunctive theory. On this theory, there is an exclusive disjunction: either an action or an event (in one sense). It follows that in that sense basic actions do not have events intrinsic to them.

Some problems in John Searle's The Construction of Social Reality. I express some doubts about his constitutive v. regulative rule distinction, and press some objections against his unanalysed idea of acceptance or agreement.

An analysis of the theses of social holism and individualism, and arguments for the metaphysical integrity and irreducibility of both social properties and social entities. The last chapter discusses explanation in social science.

Resumen -/- Las personas somos absolutamente diferentes de las cosas, no cabe ninguna duda al respecto. No obstante, sí debemos diferenciar nítidamente entre los individuos y el concepto de “persona”. Así pues, la persona posee un “horizonte interior”, absolutamente novedoso y que le caracteriza como ser en aproximación a la Verdad y a la Libertad, las cuales no sólo son específicas del propio humano, sino que le son necesarias en cuanto remedios contra la desolación y la tiranía. Asimismo, una sociedad (...) puede ser tiránica en varios sentidos, pero Manuel Mindán sostiene que, para que no lo sea, el individuo entendido como “persona” debe primar siempre sobre el grupo gregario y cerrado. -/- Palabras clave: Manuel Mindán, persona, “Horizonte interior”, sociedad gregaria, “nostrismo”, individualismo, totalitarismo -/- Person as Inner Horizon in the Philosophy of Manuel Mindán -/- Abstract -/- People and things are quite different, but we must distinguish clearly between individuals and the concept of “person”. So, the person possesses an “inner horizon”, completely new, and characterizes him as being on approach to Truth and Freedom -which are specific to the human itself-, while both are needed as remedies against desolation and tyranny. Likewise, a society can be tyrannical, in several senses. However, Manuel Mindán believes that the individual understood as a “person” must always prevail over the gregarious and closed group.Keywords: Manuel Mindán, person, “inner horizon”, things, individuals, “Gregarious Group”, “nostrismo”, truth, freedom, individualism, totalitarianism. -/- Keywords: Manuel Mindán, Person, “inner horizon”, society, “nostrismo”, Individualism, totalitarianism -/- Recepción del original: 15/09/14 Aceptación definitiva: 08/12/14. (shrink)

Book synopsis: This collection of previously unpublished essays presents the newest developments in the thought of international scholars working on the explanation of action. The contributions focus on a wide range of interlocking issues relating to agency, deliberation, motivation, mental causation, teleology, interprative explanation and the ontology of actions and their reasons. Challenging numerous current orthodoxies, and offering positive suggestions from a variety of different perspectives, this book provides essential reading for anyone interested in the explanation of action.

Mind-body parallelism is the view that mind and body stand in the same “order and connection,” as Spinoza put it, or that corresponding mental and physical states have corresponding causal explanations in terms of other mental and physical states. This dissertation investigates the nature and role of mind-body parallelism, as well as other forms of parallelism, in Spinoza’s philosophy of mind. In doing so, it also considers how Spinoza’s views relate to current discussions. In present-day philosophy of mind, mind-body parallelism (...) is almost never defended. It is seen as a historical dead-end with insurmountable problems. By contrast, I argue that parallelism powerfully responds to the post-Cartesian mind-body problem (which remains with us today) and that it points a way forward in current debates. The dissertation contains five independent chapters. After an introduction that situates parallelism in relation to both Spinoza’s time and to present discussions, Chapter 1 presents an argument for parallelism aimed at a present-day audience. Chapter 2 discusses Spinoza’s own arguments for parallelism. Both chapters help to clarify what parallelism is, in part by distinguishing between several versions of the view. Chapter 3 discusses what is often considered parallelism’s most problematic feature, its rejection of mind-body interaction. I argue that by distinguishing between the post-Cartesian context in which Spinoza wrote and present-day discussions, we can see that parallelism is compatible with mental causation. Chapters 4 and 5, finally, discuss specific ways in which parallelism is at work in Spinoza’s view of the mind. In Chapter 4, I argue that parallelism is at work in Spinoza’s interesting and distinctive positions on the nature of agency and motivation. In Chapter 5, I show the role of parallelism in his representationalist theory of consciousness. A guiding thread throughout the dissertation is that parallelism presents a distinctive and interesting way to combine realism, non-reductionism and naturalism in relation to those features of human self-understanding that seem difficult to fit into a naturalistic worldview. (shrink)

Human eggs for basic, fertility and stem-cell research are in short supply. Many experiments that require their use cannot be carried out at present, and, therefore, the benefits that could emerge from these are either delayed or never materialise. This state of affairs is problematic for scientists and patients worldwide, and it is a matter that needs our attention. Recent advances in chimera research have opened the possibility of creating human/non-human animal chimeras intended for human gamete production (chimeras-IHGP). In this (...) paper, I examine four arguments against the creation of such chimeras and prove that all of them are found wanting. I conclude by showing that there is a strong moral reason for scientists to pursue this research avenue. (shrink)

This open access book revises Kant’s ethical thought in one of its most notorious respects: its exclusion of animals from moral consideration. The book gives readers in animal ethics an accessible introduction to Kant’s views on our duties to others, and his view that we have only ‘indirect’ duties regarding animals. It then investigates how one would have to depart from Kant in order to recognise that animals matter morally for their own sake. Particular attention is paid to Kant’s ‘Formula (...) of Humanity,' the role of autonomy and the moral law, as well as Kant’s notions of practical reason and animal instinct. The result is a deliberately amended version of Kantianism which nevertheless remains faithful to central aspects of Kant’s thought. The book’s final part illustrates the framework’s use in applied contexts, addressing the issues of using animals as mere means, the ethics of veganism and vegetarianism, and environmental protection. Nico Dario Müller shows how, when furnished with duties to animals, Kant's moral philosophy can be a powerful resource for animal ethicists. (shrink)

Animal ethics has often been criticized for an overreliance on “ideal” or even “utopian” theorizing. In this article, I recognize this problem, but argue that the “nonideal theory” which critics have offered in response is still insufficient to make animal ethics action-guiding. I argue that in order for animal ethics to be action-guiding, it must consider agent-centered theories of change detailing how an ideally just human-animal coexistence can and should be brought about. I lay out desiderata that such a theory (...) of change should suffice so as to be helpful in guiding action. Specifically, a theory of change should determine (1) who needs to do what in order for ideal justice to be achieved in the long run, (2) who should be expected to refuse compliance and how they should be moved to comply, and (3) why specific intermediate steps are necessary. I show how previous “nonideal” contributions, though helpful in other ways, are insufficiently determinate on these points and I sketch a (still somewhat utopian) theory of change for one specific context. This brings animal ethics a crucial step closer to being action-guiding in the real world. (shrink)